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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels

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The activity of PFK-1 is modulated by various cytoplasmic substances, including adenosine triphosphate (ATP), adenosine diphosphate (ADP), F-6-P, and fructose-2,6-bisphosphate (F-2,6-BP)

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